Sarcoidosis Answers for Physicians, Nurses and Patients

Here at SarcInfo, between 2002 and 2004, we identified the cause of Sarcoidosis, and successfully trialled a curative antimicrobial therapy. During 2005 and 2006 the US FDA designated the antibiotics Clindamycin and Minocycline as Orphan Products in the treatment of Sarcoidosis, and studies are ongoing elsewhere.

For information about this breakthrough, please post your questions at the current study-site, or the Autoimmunity Research Foundation.
 
This archive of the historic study is maintained by volunteers from the Foundation. The material here provides useful background, but much of it is now out-of-date.

** Patient Tutorials **

 Click here to read "WHY DID I GET SARCOIDOSIS? WHY ME? 

  Click here to read "REMISSION IN SARCOIDOSIS"  

 How a Pathologist can see Bacteria causing Sarcoidosis 

"How does Doctor measure my ACE, and my D-metabolites?"

 Weaning from Prednisone

 Protecting your eyes in Sarcoidosis

Vit.D and Calcium in Sarcoidosis

Hypervitaminosis D Symptoms    The SarcInfo F.A.Q.

Medical Abbreviations          CBC Radio Show

Protocol Phase 1-First 3 months

  

** Papers for Physicians **

Antibacterial Therapy induces Remission 

Implications for Autoimmune Disease 
(Here is Fulltext preprint)

Antibacterial mechanisms for ARBs 

Antibiotics in Sarcoidosis- The 1st Year 

Rationale for abx in Sarcoidosis 

1,25-D and Angiotensin II

"New Treatments Emerge.."

Jarisch-Herxheimer in Sarcoidosis

Vit.D and Calcium in Sarcoidosis

Protocol Phase 1-First 3 months

The NIH ACCESS Study finds Sarcoidosis does not go away - Click here to see, and print, the brochure


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 Endocrine Disruptors
Author: Ken (---.proxy.aol.com)
Date:   05-26-02 11:08

: J Endocrinol Invest 2000 Dec;23(11):771-81

Occupational and environmental agents as endocrine disruptors: experimental and human evidence.

Baccarelli A, Pesatori AC, Bertazzi PA.

Institute of Endocrine Sciences, Ospedale Maggiore, IRCCS, and EPOCA Research Center for Occupational, Clinical and Environmental Epidemiology, University of Milan, Italy. Andrea.Baccarelli@unimi.it

In the last few years great concern has arisen from the description of adverse endocrine effects of several occupational and environmental chemical agents on human and/or wildlife health. Such agents may exert their effects directly, specifically binding to hormone receptors, and/or indirectly, by altering the structure of endocrine glands and/or synthesis, release, transport, metabolism or action of endogenous hormones. Many studies have been focused on the outcomes of the exposure to those chemicals mimicking estrogenic or androgenic actions. Nonetheless, the disruption of other hormonal pathways is not negligible. This paper reviews the experimental and human evidence of the effects of occupational and environmental chemical agents on hypothalamus-pituitary unit, pineal gland, parathyroid and calcium metabolism and adrenal glands.

PMID: 11194713
 
 Re: Endocrine Disruptors
Author: Admin (---.cu27.vnnyca.adelphia.net)
Date:   05-26-02 11:27

Ken, that's very true. The obvious case of the ability of the drug Pravachol to interfere with the operation of our immune systems should awaken us to the possibility of endocrine disruptors.

There is also a link at the bottom of this page to a slideshow teaching how genetic mutations can occur during our lives in response to certain pathogens with which we may come in contact.

Remember, there are two important things we must understand if we are to come to grips with this syndrome called sarcoidosis:

1: The individual posseses, or develops (by exposure to endocrine disruptors and genetic mutagens) the predisposition towards an uncontrolled immune system reaction

2: Subsequent exposure to a triggering agent (eg: bacterial or inhaled agents) initiates the uncontrolled immune reaction

Understanding and controlling that immune reaction is the task that faces the sarc patient. Once the predisposition is in place there is very little liklihood it will ever go away. The talk about 'remission' refers only to controlling the symptoms resulting from each episode of the uncontrolled immune reaction.

Many patients, especially those whose immune systems are responding to systemic bacteria, may never be able to achieve effective remission. Nevertheless, as our understanding of the inflammatory process evolves, it is becoming progressively easier to deal with the symptoms that result, and to craft a reasonably 'normal' lifestyle.

..Trevor..
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Historical perspective on Sarcoidosis:


  1. The John's Hopkins Vasculitis Center: Prednisone Side Effects (incl. PHOTOS and PHOTOGRAPHS)
  2. Steroid-Treated patients Have higher risk of Cardiac problems
  3. "Evidence Growing That Inhaled Steroids, Like Steroid Pills, Can Cause Bone Loss"
  4. "Corticosteroids contribute to the prolongation of the disease by delaying resolution"
  5. "No data to suggest that corticosteroid therapy alters long-term disease progression"
  6. Cochrane Review - "Oral and Inhaled Corticosteroids have no discernible effect on lung function"
  7. Prednisone Improves Symptoms but not Lung Function in Sarcodiosis
  8. There is no conclusive evidence that corticosteroids affect the development of irreversible pulmonary damage
  9. Clinical Guideline For Treatment Of Arthritis Pain
  10. Angiotensin II receptor on BALF macrophages from Japanese patients with active sarcoidosis

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