Sarcoidosis Answers for Physicians, Nurses and Patients

Here at SarcInfo, between 2002 and 2004, we identified the cause of Sarcoidosis, and successfully trialled a curative antimicrobial therapy. During 2005 and 2006 the US FDA designated the antibiotics Clindamycin and Minocycline as Orphan Products in the treatment of Sarcoidosis, and studies are ongoing elsewhere.

For information about this breakthrough, please post your questions at the current study-site, or the Autoimmunity Research Foundation.
 
This archive of the historic study is maintained by volunteers from the Foundation. The material here provides useful background, but much of it is now out-of-date.

** Patient Tutorials **

 Click here to read "WHY DID I GET SARCOIDOSIS? WHY ME? 

  Click here to read "REMISSION IN SARCOIDOSIS"  

 How a Pathologist can see Bacteria causing Sarcoidosis 

"How does Doctor measure my ACE, and my D-metabolites?"

 Weaning from Prednisone

 Protecting your eyes in Sarcoidosis

Vit.D and Calcium in Sarcoidosis

Hypervitaminosis D Symptoms    The SarcInfo F.A.Q.

Medical Abbreviations          CBC Radio Show

Protocol Phase 1-First 3 months

 

** Papers for Physicians **

Antibacterial Therapy induces Remission 

Implications for Autoimmune Disease 
(Here is Fulltext preprint)

Antibacterial mechanisms for ARBs 

Antibiotics in Sarcoidosis- The 1st Year 

Rationale for abx in Sarcoidosis 

1,25-D and Angiotensin II

"New Treatments Emerge.."

Jarisch-Herxheimer in Sarcoidosis

Vit.D and Calcium in Sarcoidosis

Protocol Phase 1-First 3 months

The NIH ACCESS Study finds Sarcoidosis does not go away - Click here to see, and print, the brochure


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 PET scan used for neurosarcoidosis
Author: pages2 (---.kc.rr.com)
Date:   04-07-02 16:45

"A second case of NSCLC depicting symmetric involvement of the mediastinum was shown. This etiology of this case was sarcoidosis."

 
 Re: PET scan used for neurosarcoidosis
Author: Admin (207.175.253.---)
Date:   04-07-02 16:53

PET is Positron Emission Tomography. I did some research on it during my PhD and then later helped design a computer for the PET unit designed by Hamamatsu Photonics in Japan.

A PET scanner receives weak radiation emitted when chemicals decay as they are metabolized, and gives a graphical representation of what areas of the anatomy are most active. The one at Hamamatsu was big, just like a CAT scanner. There was a huge Cyclotron room right next to the PET, as the glucose they were using for testing had to be made radioactive within 20 minutes of use!

In the case you have referenced, the sarcoidosis patient showed problems with the mediastinum, an area of the brain, which was not functioning correctly. Unlike in cancer, where both sides of the mediastinum would most likely be affected, this patient was exhibiting asymettric metabolization.

PET is neat technology... It is definitely the best way to see a malfunctioning brain, but gives you little clue as to what is causing the malfunction. As the reference says, 15% of sarc patients referred to them have some observable abnormality (the research cautions this high number may be biased by the referral process). Based on the comments of patients posting on the sarc message boards I would agree with that number, as PET is a very sensitive test. However, what we really need is an explanation of why, and PET really gives us no information other than that an abnormality exists.

..trevor..

 
 Re: PET scan used for neurosarcoidosis
Author: Cher (144.138.225.---)
Date:   05-05-02 12:40

Hi Everyone,
Is a PET scan much different to an MRI? Which would be the better option for Neuro Sarc diagnosis? Finally in one of the other postings someone (sorry I've forgotten which posting & which person) talked about a Nerve Conduction test. Is this also an indicative test for Neuro Sarc?
Cheers everyone ... Stay Positive ... Cher

 
 Re: PET scan used for neurosarcoidosis
Author: Admin (---.vnnyca.adelphia.net)
Date:   05-05-02 13:01

Cher,
PET scans can determine activity in the brain by highlighting areas which are metabolising radioactive glucose. The machines are few and far between, but they work on a totally different principle from either MRI or CAT.

If you had true, clinical, Neurosarcoidosis, then the assymmetrical activity in your cortex should be easily shown in a PET scan. However, by the time that Neurosarcoidosis is visible on any instrument, the patient is usually pretty sick. At the recent Sarc Conference, a paper was given which showed asymmetric activity in somebody who had gone blind, for example. I doubt that any of us have the disease at this level of severity. Neuroscience is still pretty imprecise

..Trevor..

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Historical perspective on Sarcoidosis:


  1. The John's Hopkins Vasculitis Center: Prednisone Side Effects (incl. PHOTOS and PHOTOGRAPHS)
  2. Steroid-Treated patients Have higher risk of Cardiac problems
  3. "Evidence Growing That Inhaled Steroids, Like Steroid Pills, Can Cause Bone Loss"
  4. "Corticosteroids contribute to the prolongation of the disease by delaying resolution"
  5. "No data to suggest that corticosteroid therapy alters long-term disease progression"
  6. Cochrane Review - "Oral and Inhaled Corticosteroids have no discernible effect on lung function"
  7. Prednisone Improves Symptoms but not Lung Function in Sarcodiosis
  8. There is no conclusive evidence that corticosteroids affect the development of irreversible pulmonary damage
  9. Clinical Guideline For Treatment Of Arthritis Pain
  10. Angiotensin II receptor on BALF macrophages from Japanese patients with active sarcoidosis

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