Sarcoidosis Answers for Physicians, Nurses and Patients

Here at SarcInfo, between 2002 and 2004, we identified the cause of Sarcoidosis, and successfully trialled a curative antimicrobial therapy. During 2005 and 2006 the US FDA designated the antibiotics Clindamycin and Minocycline as Orphan Products in the treatment of Sarcoidosis, and studies are ongoing elsewhere.

For information about this breakthrough, please post your questions at the current study-sites of the Autoimmunity Research Foundation.
 
This archive of the historic study is maintained by volunteers from the Foundation. The material here provides useful background, but most of this site is now out-of-date.

 

** Patient Tutorials **

 Click here to read "WHY DID I GET SARCOIDOSIS? WHY ME? 

  Click here to read "REMISSION IN SARCOIDOSIS"  

 How a Pathologist can see Bacteria causing Sarcoidosis 

"How does Doctor measure my ACE, and my D-metabolites?"

 Weaning from Prednisone

 Protecting your eyes in Sarcoidosis

Vit.D and Calcium in Sarcoidosis

Hypervitaminosis D Symptoms    The SarcInfo F.A.Q.

Medical Abbreviations          CBC Radio Show

Protocol Phase 1-First 3 months

  

** Papers for Physicians **

Antibacterial Therapy induces Remission 

Implications for Autoimmune Disease 
(Here is Fulltext preprint)

Antibacterial mechanisms for ARBs 

Antibiotics in Sarcoidosis- The 1st Year 

Rationale for abx in Sarcoidosis 

1,25-D and Angiotensin II

"New Treatments Emerge.."

Jarisch-Herxheimer in Sarcoidosis

Vit.D and Calcium in Sarcoidosis

Protocol Phase 1-First 3 months

The NIH ACCESS Study finds Sarcoidosis does not go away - Click here to see, and print, the brochure


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 Infection location and herxheimer location
Author: Lynne (205.160.182.---)
Date:   11-04-03 13:26

As I'm going through the different manifestations of this herx thing, I have to wonder about the orginal infection. That is, if one took an antibiotic that destroyed cell walls (as is the mechanism of many antibiotics), would the herx be worse coming from there? I'm thinking of all the times I had to take penicillin for strep throat as a child, and all the sinus and urinary track infections that were treated with amoxicillin over the years.

I'm having some uncomfortable urinary symptoms in addition to tinnitis and sinus drainage and sore throat. This comes about 36 hours after the minocycline. I guess there would be good reason for the CWD bacteria to be where the original bacteria was! I was expecting a sarc-like flare of more recent problems but not the historic ones, too.

Or, could my urinary track be getting irritated by the toxins leaving my body?

Lynne
 
 Re: Infection location and herxheimer location
Author: Admin (---.vnnyca.adelphia.net)
Date:   11-04-03 13:37

Lynne,
One can never be sure, but my suspicion is that the urinary-tract herx indicates CWD were living in that area. You might also ask Doc to check your kidney enzymes, and to check for fungal infections. But I suspect it will eventually go away, as all herx does.

The microbes do spread pretty well throughout the body. While the sarcoid inflammation goes untreated with abx, or whenever it is treated with immunosuppressants like MTX and prednisone, the microbes will continue to gradually colonize more and more of the body.

Although it is not always reliable to place herx pain as being from a specific area (for example, heart pain can often appear in the left arm) nevertheless it is not a bad guesstimate to assume that pain in an area means bugs in that area.

It is certainly reliable to say that herx pain in an area, which goes away after several months of therapy, is a definite indicator that susceptible cell-dwelling bacteria were there.

..Trevor..
 
 Re: Infection location and herxheimer location
Author: Lynne (205.160.182.---)
Date:   11-04-03 15:38

Trevor:

Thanks for your reply. I had thought the the CWD bacteria spread throughout your body, but it's just alarming that they never leave the orginal sites, unless they just die off, or burn out or have a finite life span inside some types of tissue.

This is a different issue, but I've lost weight (not by dieting, which I do very poorly) and I came across an article on PubMed that might explain it. I wish I knew how to insert a link. It was from the Journal of Hypertension Nov. 2000. It concluded that skeletal muscle TNF-alpha is linked to insulin resistance and hypertension, and that angiotensin II may be a factor that regulates TNF-alpha. SO--by taking a ACE inhibitor or ARB--they used both in the experiment--you may be treating insulin resistance, which is a (proposed) problem among hypothyroid sufferers and others who have trouble losing weight.

I had thought that those unwanted extra pounds had come off because of the minocycline, but maybe it's from the Enalapril. (I can get Enalapril. Not Benicar, yet).

Lynne
 
 Re: Infection location and herxheimer location
Author: Margo (---.dsl.intrex.net)
Date:   11-04-03 20:44

Lynne,

I think this is the article:

J Hypertens. 2000 Nov;18(11):1605-10.


The contribution of skeletal muscle tumor necrosis factor-alpha to insulin resistance and hypertension in fructose-fed rats.

Togashi N, Ura N, Higashiura K, Murakami H, Shimamoto K.

PMID: 11081773

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11081773&dopt=Abstract

Margo
 
 Re: Infection location and herxheimer location
Author: Admin (---.vnnyca.adelphia.net)
Date:   11-04-03 20:51

Lynne,
TNF-alpha is one of the caustic chemicals (cytokins) formed when Angiotensin II bonds with the Type 1 receptors on the inflammatory phagocytes. No Angiotensin II bonding means no TNF-alpha generation.

The full description of the biochemistry is at this URL (including the notes about TNF-alpha).

..Trevor..
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This is an archive site, membership and posting are no longer allowed.

Historical perspective on Sarcoidosis:


  1. The John's Hopkins Vasculitis Center: Prednisone Side Effects (incl. PHOTOS and PHOTOGRAPHS)
  2. Steroid-Treated patients Have higher risk of Cardiac problems
  3. "Evidence Growing That Inhaled Steroids, Like Steroid Pills, Can Cause Bone Loss"
  4. "Corticosteroids contribute to the prolongation of the disease by delaying resolution"
  5. "No data to suggest that corticosteroid therapy alters long-term disease progression"
  6. Cochrane Review - "Oral and Inhaled Corticosteroids have no discernible effect on lung function"
  7. Prednisone Improves Symptoms but not Lung Function in Sarcodiosis
  8. There is no conclusive evidence that corticosteroids affect the development of irreversible pulmonary damage
  9. Clinical Guideline For Treatment Of Arthritis Pain
  10. Angiotensin II receptor on BALF macrophages from Japanese patients with active sarcoidosis

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