Sarcoidosis Answers for Physicians, Nurses and Patients

Here at SarcInfo, between 2002 and 2004, we identified the cause of Sarcoidosis, and successfully trialled a curative antimicrobial therapy. During 2005 and 2006 the US FDA designated the antibiotics Clindamycin and Minocycline as Orphan Products in the treatment of Sarcoidosis, and studies are ongoing elsewhere.

For information about this breakthrough, please post your questions at the current study-sites of the Autoimmunity Research Foundation.
 
This archive of the historic study is maintained by volunteers from the Foundation. The material here provides useful background, but most of this site is now out-of-date.

 

** Patient Tutorials **

 Click here to read "WHY DID I GET SARCOIDOSIS? WHY ME? 

  Click here to read "REMISSION IN SARCOIDOSIS"  

 How a Pathologist can see Bacteria causing Sarcoidosis 

"How does Doctor measure my ACE, and my D-metabolites?"

 Weaning from Prednisone

 Protecting your eyes in Sarcoidosis

Vit.D and Calcium in Sarcoidosis

Hypervitaminosis D Symptoms    The SarcInfo F.A.Q.

Medical Abbreviations          CBC Radio Show

Protocol Phase 1-First 3 months

  

** Papers for Physicians **

Antibacterial Therapy induces Remission 

Implications for Autoimmune Disease 
(Here is Fulltext preprint)

Antibacterial mechanisms for ARBs 

Antibiotics in Sarcoidosis- The 1st Year 

Rationale for abx in Sarcoidosis 

1,25-D and Angiotensin II

"New Treatments Emerge.."

Jarisch-Herxheimer in Sarcoidosis

Vit.D and Calcium in Sarcoidosis

Protocol Phase 1-First 3 months

The NIH ACCESS Study finds Sarcoidosis does not go away - Click here to see, and print, the brochure


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 Tests to monitor Sarc Progression/Regression
Author: Tom Rogers (---.biz.rr.com)
Date:   10-15-03 13:12

Are there specific tests that one should have to monitor the progression/regression of Sarcoidosis while using this ABX protocol, BESIDES the D-Ratios? And what should the frequency of these tests be?

Tests I am thinking of are:

Inflammatory Markers:
CRP level
ACE level
Homocystein level
Lymphocytes

Chest CT scans
Chest X-Rays
PFTs
Brain MRIs - MRAs
Heart Thalium scans
Twelve lead EKGs
Event monitors - holter monitors
Echocardiograms (resting or stress)
Liver function tests
Kidney function tests

I am thinking it would be best to go by something other than "feeling better", as that can be "relative" at times. I would like some hard evidence to show my doc that this protocol is working exactly as it should. This in turn should get the attention of more docs, if we can have our docs publish our case histories in their journals as well.

Thanx,

-Tom
 
 Re: Tests to monitor Sarc Progression/Regression
Author: Admin (---.vnnyca.adelphia.net)
Date:   10-15-03 13:35

Tom,
The Th1/Th2 cytokines can be monitored. The soluble InterLeukin 2 Receptor test (sIL2R) is one Doc can order. None are as good as 1,25-D of course.

Triglycerides and Alkaline Phosphatase are also reliable markers (if they were initially elevated).

Most of us who have been on antibiotics for extended periods do in fact show CT and MRI improvements. In some cases, quite remarkable radiographic improvements, quite quickly.

But what's wrong with feeling better? Getting a good nights sleep? Being able to put in a good 8 hours work?

Methotrexate treatment is regarded as 'successful' if it slows the progression of the disease. Why would Doc require a different standard for abx therapy?

And what is the resistance to 1,25-D? Doesn't Dr John Adams, Head of Endocrinology at Cedars Sinai (UCLA) cut any weight when he describes how 1,25-D actually causes the formation of macrophages in the granuloma?

..Trevor..
 
 Re: Tests to monitor Sarc Progression/Regression
Author: Tom Rogers (---.twcny.rr.com)
Date:   10-16-03 14:30

Trevor,

No resistance to the 1,25-D at all, but my D Ratio was 1.75 (ACE 135) so I didn't think that would be a good marker for my case.

-Tom
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This is an archive site, membership and posting are no longer allowed.

Historical perspective on Sarcoidosis:


  1. The John's Hopkins Vasculitis Center: Prednisone Side Effects (incl. PHOTOS and PHOTOGRAPHS)
  2. Steroid-Treated patients Have higher risk of Cardiac problems
  3. "Evidence Growing That Inhaled Steroids, Like Steroid Pills, Can Cause Bone Loss"
  4. "Corticosteroids contribute to the prolongation of the disease by delaying resolution"
  5. "No data to suggest that corticosteroid therapy alters long-term disease progression"
  6. Cochrane Review - "Oral and Inhaled Corticosteroids have no discernible effect on lung function"
  7. Prednisone Improves Symptoms but not Lung Function in Sarcodiosis
  8. There is no conclusive evidence that corticosteroids affect the development of irreversible pulmonary damage
  9. Clinical Guideline For Treatment Of Arthritis Pain
  10. Angiotensin II receptor on BALF macrophages from Japanese patients with active sarcoidosis

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